This article is part of our FanDuel Fantasy Football series.
QUARTERBACK
Baker Mayfield, CLE at TB ($7,100): The Tampa pass defense has been atrocious this season and is at the bottom of the league in most stats. They're at the bottom of the league in the following passing defensive categories: YPA (9.3), yards per game (356!), touchdowns (16) and passer rating (129.5). The 356 passing yards against indicates this should be a high-scoring game with both teams moving the ball up and down the field. Not surprisingly, the Bucs have given up the most fantasy points of any team to opposing quarterbacks by 2.8 points more than the second worst team. Baker comes in as the 14th highest-priced quarterback out of 20 on the main slate, showing he's a good bargain with a lot of upside.
RUNNING BACK
Peyton Barber, TB vs. CLE ($6,100): Barber is clearly the main back for Tampa and now has at least 17 touches in three of his first five games this season. Out of the teams playing the main slate of games this week on FanDuel, the Brown have allowed the fourth most fantasy points to opposing running backs. Barber is a capable pass catcher (4-24-1 last week), and if the game stays close as Vegas expects, Barber will play a key role for Tampa.
Tarik Cohen, CHI vs. NE ($6,600): Cohen has been heavily involved in the Bears' offense over their last two games, with 295 yards from scrimmage to go along with a rushing and receiving touchdown. Those stats led to 26.9 and 19.6 fantasy points in those games, and this week's home matchup against NE could see Cohen getting a lot of targets again. Another fumble by Jordan Howard could land him in the doghouse and give Cohen an even bigger workload.
WIDE RECEIVER
Jarvis Landry, CLE at TB ($6,500): Even in cash games, using Landry with Baker Mayfield makes a lot of sense (and David Njoku [$5,700] as well). Landry continues to be Mayfield's best target and has at least 10 targets in all four games in which Mayfield has played. Tampa has given up 10 touchdowns to opposing wide receivers and is giving up the second most fantasy points to the position. Taking out the Chargers game last week (which helped his price drop), Landry has at least 9.4 fantasy points in every game this season, setting a solid floor for him.
Josh Reynolds, LAR at SF ($5,100): Reynolds comes in only $600 over the minimum price for a wide receiver and is in a great fantasy spot as Cooper Kupp's replacement as the third wide receiver. The Rams run three-wide receiver sets on 95 percent of their plays, meaning Reynolds will get a season-high in snaps with soft coverage as the low man on the receiving totem pole. At 6-3 he's a bigger target than Brandin Cooks (5-10) or Roberts Woods (6-0), making him a good red zone target for Jared Goff. Just watch to make sure Reynolds' hand injury isn't bad enough to keep him out of this game.
TIGHT END
Zach Ertz, PHI vs. CAR ($7,500): Ertz seems to always have a good fantasy game at a position that's been a mess with injuries and ineffectiveness. With Carson Wentz under center, his worst fantasy game (four) was 9.8 fantasy points, and his best was 22. Surprisingly, the Panthers have been very bad against the tight end spot this season, giving up the third most fantasy points of any team playing on the main slate.
FLEX
Jermaine Kearse, NYJ vs. MIN ($5,000): Right now Kearse is the healthiest of the Jets' wide receivers with Quincy Enunwa out with an ankle injury, Terrelle Pryor dealing with a groin issue and Robby Anderson with a balky hamstring. Anderson practiced Thursday and should be fine for this one, so it'll likely be him and Kearse lined up opposite each other at wide receiver. Kearse had 10 targets last week and could be in line for something similar with limited options at Sam Darnold's disposal. Think of Kearse as a punt play for GPPs who should be avoided in cash contests.
DEFENSE
Jacksonville Jaguars vs. Houston ($4,400): Now seems the perfect time to take Jacksonville, who is the fourth-highest priced defense this week. They're coming off a poor performance in Dallas, which will keep they low-owned due to recency bias, yet they have as much upside this week as any defense. Houston has allowed a league-high 70 hits on Deshaun Watson, and he's turned the ball over nine times this season including at least one interception in every game. Houston doesn't have much in the way of a running attack either, averaging only 3.9 yards per carry as a team (including Watson's 5.6 mark), the seventh-lowest in football.
