Hotspots on this week's NFL injury report include Kansas City's offense and defense, Pittsburgh's defense, Detroit's secondary, and Arizona's offensive line and secondary.
Make sure to keep up with NFL breaking news throughout the weekend, especially Sunday morning when inactive lists are released at 11:30 a.m. ET for the early games.
Below you'll find four different categories, with our lists including key offensive linemen and defensive players whose absences might impact fantasy decisions. The bottom section, for potential game-day decisions, is sorted by kickoff times. It can be used as a checklist/cheatsheet for Sunday when inactives come out and we need to adjust lineups.
Good to Go 💯
Players that missed their team's previous game are listed in bold.
Cleared to Play this Week
QB Lamar Jackson (illness)
QB Geno Smith (shoulder)
RB RJ Harvey (ribs)
RB Saquon Barkley (neck)
RB Javonte Williams (neck)
WR Alec Pierce (Achilles)
WR CeeDee Lamb (illness)
WR Mike Evans (collarbone)
WR Tetairoa McMillan (foot/ankle)
WR Tyler Lockett (hip)
WR Tre' Harris (hip)
WR Pat Bryant (hamstring)
WR Rashod Bateman (ankle)
WR Hollywood Brown (personal)
TE Dalton Kincaid (knee)
TE Kyle Pitts (ankle)
TE Darren Waller (rest/knee)
TE Cade Otton (knee)
A fully clean final injury report for Bucs — nobody even questionable — while Panthers tackle Ikem Okwonu is questionable. pic.twitter.com/nKxLQR1CeG
— Greg Auman (@gregauman) December 19, 2025
Ruled Out/Doubtful 🚑
New absences listed in bold (guys that played in the previous game).
Out/Doubtful/IR
QB Jayden Daniels (IR - elbow)
QB Patrick Mahomes (IR - knee)
QB Tua Tagovailoa (benched, not injured)
RB Bam Knight (IR - ankle)
RBs Devin Neal (IR - hamstring) & Alvin Kamara (knee)
RB Dylan Sampson (calf)
RB Bhayshul Tuten (finger)
WRs Rashee Rice & Tyquan Thornton (concussions)
WRs Luther Burden (ankle) & Rome Odunze (heel)
WR Garrett Wilson (IR - knee)
WR Devaughn Vele (IR - shoulder)
WR Noah Brown (IR - rib)
TE Mason Taylor (neck)
TE Noah Fant (ankle)
TE Colson Yankoff (ankle)
TE David Njoku (knee)
TE Josh Whyle (concussion)
Potential Workload Beneficiaries (From Injuries Above)
QB Marcus Mariota
QB Patrick Mahomes
QB Quinn Ewers
RBs Michael Carter & Emari Demercado
RBs Audric Estime & Evan Hull
RB Trayveon Williams
RBs Travis Etienne & LeQuint Allen
WRs Xavier Worthy, Hollywood Brown, JuJu Smith-Schuster, Jalen Royals
WRs DJ Moore, Olamide Zaccheaus & Devin Duvernay
WRs Adonai Mitchell & John Metchie
WRs Mason Tipton (Q - illness), Kevin Austin & Dante Pettis
WRs Jaylin Lane & Treylon Burks
TE Jeremy Ruckert
TE Mike Gesicki
TEs John Bates & Ben Sinnott
TEs Harold Fannin & Blake Whiteheart
TEs Luke Musgrave & John FitzPatrick
No surprise but Gannon confirmed that Michael Carter will be the starting running back this week with Bam Knight out
— Theo Mackie (@theo_mackie) December 19, 2025
Key Defensive Players + Offensive Linemen
OLB T.J. Watt (lung), OLB Nick Herbig (D - hamstring), CB James Pierre (calf), G Isaac Seumalo (triceps)
T Paris Johnson (knee), G Evan Brown (personal)
CB Max Melton (heel), S Jalen Thompson (hamstring)
CB Mike Hughes (ankle)
LB Trevin Wallace (shoulder)
CB Denzel Ward (calf)
T Tyler Guyton (ankle), CB DaRon Bland (foot)
S Kerby Joseph (knee)
LB Leo Chenal (shoulder), CB Trent McDuffie (knee), DT Derrick Nnadi (illness)
T Jawaan Taylor (triceps), T Jaylon Moore (knee)
S Minkah Fitzpatrick (calf)
DT Javon Hargrave (thigh)
OLB Kayvon Thibodeaux (shoulder), DT Rakeem Nunez-Roches (ankle)
G Cesar Ruiz (ankle)
DT Jalen Carter (shoulder), T Lane Johnson (foot)
T Laremy Tunsil (oblique)
K Matt Prater (quad)
LB Robert Spillane (ankle)
CB Chidobe Awuzie (D - foot), LB Teddye Buchanan (IR - knee)
Listed as Questionable - Should Play 👍
WR Van Jefferson (back) + TE Gunnar Helm (toe)
.@Titans final injury report vs @Chiefs pic.twitter.com/Pbklp0EiFh
— Jim Wyatt (@jwyattsports) December 19, 2025
Truly Questionable / Game-Time Decisions 🤔
Players with key fantasy repercussions listed in bold.
Saturday
RBs Josh Jacobs (knee) & Chris Brooks (chest)
RB D'Andre Swift (groin)
WRs Christian Watson (chest) & Dontayvion Wicks (ankle)
TE Cole Kmet (ankle/knee)
Jacobs didn't practice this week but said he'll play anyway. Swift also seems likely to play, dealing with the same groin injury that he's largely fought through without suffering a drop-off in performance. The other guys here are tougher to get a read on, but all practiced some during the week and thus appear at least 50/50 for Saturday's showdown.
Early Games
WR Quentin Johnston (groin)
WR Drake London (PCL)
WR Tee Higgins (concussion)
WR Mason Tipton (illness)
Higgins is in concussion protocol, which means the Bengals should know by Saturday morning/afternoon if he's able to play. I don't think he should play when he's suffered two concussions this season and his team doesn't have a shot at the playoffs, but it seems that's what Higgins and Co. want to do.
The Falcons are listing WR Drake London (knee) as questionable, but coach Raheem Morris told reporters he expects London to return to action on Sunday vs. Arizona.
— Tom Pelissero (@TomPelissero) December 19, 2025
Late-Afternoon Games
RBs Woody Marks (ankle) & Nick Chubb (rib)
WRs Marvin Harrison (heel) & Xavier Weaver (hamstring)
WR Christian Kirk (illness)
Chubb was a full practice participant Thursday and Friday, while
Harrison expects to play this week, but his comments almost felt like he was setting the table for disappointment (which is probably what you want to hear if you're starting Michael Wilson).
Marvin Harrison Jr. added he'll probably play through the heel injury the rest of the season.
"Just (want to) put good things on tape and help the team as much as I can. Probably playing through the injury the rest of the year, just kind of dealing with that and just go out…
— Tyler Drake (@Tdrake4sports) December 19, 2025
Primetime Games
WR Ricky Pearsall (knee/ankle) - MNF
#49ers GM John Lynch on Pearsall:
"Ricky is doing all he can to get back on the field. We'll see for Monday night — we certainly haven't ruled him out."
Via: @KNBR pic.twitter.com/kcwKzezGOM
— OurSF49ers (@OurSf49ers) December 19, 2025
Key Defensive Players + O-Linemen
T Zach Tom (knee), S Evan Williams (knee)
LT Ikem Ekwonu (knee)
G Wyatt Teller (calf)
DT Quinnen Williams (head), CB Caelen Carson (shoulder)
T Taylor Decker (shoulder), G Graham Glasgow (knee), CB Amik Robertson (hand)
CB Derek Stingley (leg), LB Azeez Al-Shaair (ankle)
RT Brian O'Neill (heel)
LB Jordyn Brooks (foot)
G Kevin Zeitler (groin), CB Jalyn Armour-Davis (Achilles), LB Arden Key (illness)
CB Carlton Davis (hip), DT Christian Barmore (knee), CB Marcus Jones (knee), LB Harold Landry (knee)
S Kyle Hamilton (ankle), LT Ronnie Stanley (knee), DT John Jenkins (illness)
LB Tatum Bethune (ankle)
OT Bernhard Raimann (elbow), CB Sauce Gardner (calf), DT DeForest Buckner (neck)
friday's practice report for #SFvsIND. pic.twitter.com/gzMUTAtXNE
— Indianapolis Colts (@Colts) December 19, 2025















