This article is part of our NFL Picks series.
We're into October and into Week 5 of the NFL season, so we're starting to get a read on every team across the league at the quarter poll. Just as we expected, the Eagles are the only undefeated team left standing and the Falcons are undefeated against the spread.
Underdogs had ruled for the first three weeks of the season, covering 60 percent of games, but Week 4 had more balanced results with favorites going 7-8-1 (44%). Over/Unders were split 8-8 this past week as well after unders had hit over 60 percent of the time in the first three weeks.
Looking ahead to this week, there is a high number of large spreads as opposed to last week when the biggest favorite, Green Bay, was the only team favored by more than seven points and it almost lost outright. Six games this week have spreads of 7.0 points are larger, with the largest spread coming in the Bills-Steelers matchup in Buffalo where the home team is a 14-point favorite as Pittsburgh begins the Kenny Pickett era.
Below, you'll find the complete odds for Week 5 of the NFL season along with my picks on spreads and totals for each matchup. Be sure to keep up with RotoWire's extensive collection of NFL picks articles each week of the season. And you can maximize your betting experience by using the best betting promos across a wide range of sportsbooks with a variety of great signup offers.
Look ahead at the NFL Week 5 odds as well, if you're interested in getting ahead of the line movement. Our own Michael Rathburn also analyzes the games with key NFL Week 5 line movement around the league.
NFL Week 5 Betting Picks For Each Game
| Date | Game Matchup | Week 5 Picks |
| Thursday, October 6 | Broncos vs. Colts | Broncos -3.0 |
| Sunday, October 9 | Packers vs. Giants | Packers -8.0 |
| Sunday, October 9 | Bills vs. Steelers | Bills -14.0 |
| Sunday, October 9 | Browns vs. Chargers | Chargers -3.0 |
| Sunday, October 9 | Jaguars vs. Texans | Jaguars -7.0 |
| Sunday, October 9 | Vikings vs. Bears | Bears +7.0 |
| Sunday, October 9 | Patriots vs. Lions | Patriots +3.0 |
| Sunday, October 9 | Saints vs. Seahawks | Seahawks +5.5 |
| Sunday, October 9 | Jets vs. Dolphins | Jets +3.5 |
| Sunday, October 9 | Buccaneers vs. Falcons | Buccaneers -8 |
| Sunday, October 9 | Commanders vs. Titans | Titans -2.5 |
| Sunday, October 9 | Panthers vs. 49ers | Panthers +6.5 |
| Sunday, October 9 | Cardinals vs. Eagles | Eagles -5.0 |
| Sunday, October 9 | Rams vs. Cowboys | Cowboys +4.5 |
| Sunday, October 9 | Ravens vs. Bengals | Ravens -3.0 |
| Monday, October 10 | Chiefs vs. Raiders | Raiders +7.5 |
Predictions for NFL Week 5
In this article, we also take a look at NFL Week 5 odds and our predictions for each NFL game.
Week 4 Record ATS: 10-6
Week 4 Record on Totals: 4-12
Season Record ATS: 18-13-1
Season Record on Totals: 8-23-1
Colts vs. Broncos
| Game | Spread | Moneyline | Total |
| Colts at Broncos | Broncos -3.0 | Denver -170; Indianapolis +155 | 43.5 |
Spread Pick: Broncos -3.0 (BetMGM)
Total Pick: Over 43.5 (DraftKings)
Eagles vs. Cardinals
| Game | Spread | Moneyline | Total |
| Eagles at Cardinals | Eagles -5.5 | Philadelphia -227; Cardinals +200 | 49.5 |
Spread Pick: Eagles -5.5 (DraftKings)
Total Pick: Under 49.5 (FanDuel)
Giants vs. Packers
| Game | Spread | Moneyline | Total |
| Giants at Packers | Packers -8 | Green Bay -360; Giants +340 | 41.5 |
Spread Pick: Packers -8 (PointsBet)
Total Pick: Under 41.5 (BetMGM)
Lions vs. Patriots
| Game | Spread | Moneyline | Total |
| Lions at Patriots | Patriots -3.0 | New England -143; Detroit +140 | 45.5 |
Spread Pick: Patriots -3 (DraftKings)
Total Pick: Over 45.5 (PointsBet)
Steelers vs. Bills
| Game | Spread | Moneyline | Total |
| Steelers at Bills | Bills -14.0 | Buffalo -800; Steelers +675 | 47.0 |
Spread Pick: Bills -14 (DraftKings)
Total Pick: Over 47 (DraftKings)
Dolphins vs. Jets
| Game | Spread | Moneyline | Total |
| Dolphins at Jets | Dolphins -3.5 | Miami -170; New York +155 | 43.5 |
Spread Pick: Jets +3.5 (FanDuel Sportsbook)
Total Pick: Over 43.5 (FanDuel Sportsbook)
Falcons vs. Buccaneers
| Game | Spread | Moneyline | Total |
| Falcons at Buccaneers | Buccaneers -8.5 | Tampa Bay -375; Atlanta +330 | 48.0 |
Spread Pick: Tampa Bay -8.5 (DraftKings)
Total Pick: Over 48.0 (PointsBet)
Seahawks vs. Saints
| Game | Spread | Moneyline | Total |
| Seahawks at Saints | Saints -5.5 | New Orleans -222; Seattle +200 | 45.5 |
Spread Pick: Seahawks +5.5 (PointsBet)
Total Pick: Over 45.5 (BetMGM)
Texans vs. Jaguars
| Game | Spread | Moneyline | Total |
| Texans at Jaguars | Jaguars -7.0 | Jacksonville -330; Houston +295 | 44.5 |
Spread Pick: Jacksonville -7.0 (FanDuel Sportsbook)
Total Pick: Over 44.5 (DraftKings Sportsbook)
Titans vs. Commanders
| Game | Spread | Moneyline | Total |
| Titans at Commanders | Titans -2.5 | Tennessee -138; Washington +130 | 42.5 |
Spread Pick: Titans -2.5 (PointsBet)
Total Pick: Under 42.5 (PointsBet)
Bears vs. Vikings
| Game | Spread | Moneyline | Total |
| Vikings vs. Bears | Vikings -7 | Minnesota -303; Bears +265 | 44.0 |
Spread Pick: Bears +7 (PointsBet)
Total Pick: Under 44.0 (BetMGM)
Chargers vs. Browns
| Game | Spread | Moneyline | Total |
| Chargers at Browns | Chargers -3 | Los Angeles -154; Browns +135 | 47.5 |
Spread Pick: Chargers -3 (DraftKings Sportsbook)
Total Pick: Under 47.5 (DraftKings Sportsbook)
49ers vs. Panthers
| Game | Spread | Moneyline | Total |
| 49ers at Panthers | 49ers -6.5 | San Francisco -265; Carolina +225 | 39.0 |
Spread Pick: Panthers +6.5 (PointsBet)
Total Pick: Over 39.0 (DraftKings)
Cowboys vs. Rams
| Game | Spread | Moneyline | Total |
| Cowboys at Rams | Rams -4.5 | Los Angeles -210; Dallas +185 | 43.5 |
Spread Pick: Cowboys +4.5 (FanDuel Sportsbook)
Total Pick: Under 43.5 (PointsBet)
Bengals vs. Ravens
| Game | Spread | Moneyline | Total |
| Bengals at Ravens | Ravens -3.0 | Baltimore -170; Cincinnati +155 | 48.5 |
Spread Pick: Ravens -3 (DraftKings Sportsbook)
Total Pick: Over 48.5 (BetMGM)
Raiders vs. Chiefs
| Game | Spread | Moneyline | Total |
| Raiders at Chiefs | Chiefs -7.0 | Kansas City -333; Las Vegas +290 | 51.5 |
Spread Pick: Raiders +7.5 (FanDuel Sportsbook)
Total Pick: Over 51.0 (PointsBet)
NFL Week 5 Best Bets
Next, we take a look at our favorite Week 5 NFL best bets at the best NFL betting sites.
BetMGM Best Bets for NFL Week 5
BetMGM offers some of the best odds available for Week 5. If you do not have a BetMGM account yet, new players at BetMGM can use the BetMGM bonus code ROTOBONUS for a risk-free bet worth up to $1,000. Here are our best bets for Week 5 at BetMGM.
- Vikings-Bears Under 44.0
- Packers-Bears Under 41.5
Caesars Sportsbook Best Bets for NFL Week 5
Let's dig into our favorite bets for NFL Week 5 at Caesars Sportsbook. If you are not registered yet, use the Caesars Sportsbook promo code ROTOFULL for a first bet on Caesars.
- Broncos -3
- Eagles -5
WynnBET Best Bets for NFL Week 5
While WynnBET may be a sportsbook that isn't as well-known as some others, the NFL Week 5 odds are more than competitive and available for some of our best bets. They also offer a great signup bonus to new players who use the WynnBET promo code, XROTO.
- Chargers -2.5
- Buccaneers -8.0
DraftKings Best Bets for NFL Week 5
Let's take a look at NFL Week 5 best bets on DraftKings Sportsbook.
- Patriots -3
- Bills-Steelers OVER 47.0
FanDuel Best Bets for NFL Week 5
FanDuel Sportsbook is an industry leader in the sports betting space. Let's take a look at our favorite betting picks with FanDuel odds.
- Jets +3.5
- Eagles-Cardinals UNDER 49.0
BetRivers Best Bets for NFL Week 5
BetRivers is one of the more underrated sportsbooks, and they are offering up to $500 in second-chance bets with the BetRivers bonus code. Bettors can use those for these picks on Week 5.
- Vikings-Bears UNDER 44.0
- Cowboys-Rams UNDER 43.0
PointsBet Best Bets for NFL Week 5
For bettors looking for a unique way to wager, try the PointsBet promo code to make your Week 5 NFL picks. You can try "PointsBetting" for Week 5 and maximize your return.
- Seahawks +5.5
- Titans -2.5
