Top MLB Betting Picks for May 22: Expert Predictions and Best Bets

MLB betting expert Michael Rathburn is back with his best bets, and he re-visits the Phillies-Rockies series, taking advantage of the home team.
Top MLB Betting Picks for May 22: Expert Predictions and Best Bets

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Top MLB Betting Picks for May 22: Expert Predictions and Best Bets

Previous article 4-0 (+3.77 units)

Season 51-54-1 (-3.15 units)

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Bullpen Rankings (updated 5/20/25)

Top 10 (Twins, Astros, Yankees, Mets, Red Sox, Phillies, Dodgers, Padres, Blue Jays, Royals). These are teams you can feel confident betting in full-game situations. 

Bottom 10 (Angels, Dbacks, Rockies, Marlins, White Sox, Orioles, Braves, Nationals, Rays, Tigers). These are teams you can feel confident betting against in full-game situations. If you want to bet these teams, only focus on first 5 inning lines.

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MLB Best Bets: 

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Philadelphia Phillies vs Colorado Rockies Betting Insights

I am going to run this back from Tuesday, and it was a little bit of a sweat, but it cashed. The Rockies are just so bad, historically bad and you have to wonder what MLB should do about it. 

When you have road favorites of -300 and run lines of -3.5 to get to even money, you know it's BAD. The Phillies have won all three games in this series by a combined score of 25-14.  The Rockies are 2-8 last 10 and 4-16 in their last 20.  

German Marquez has an ERA over 8, and he has been one of the worst pitchers in baseball. I am actually surprised the F5 Phillies total is still 3.5 even though a little more juice. I figured they would have moved it to 4.5 for Thursday's game. 

MLB Best Bets: Phillies -1.5 runs F5 for 1 unit (DraftKings -125); Phillies OVER 3.5 runs for 1 unit (DraftKings -130)

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Baltimore Orioles vs Boston Red Sox Best Bets and Predictions

This is not a wager that I have looked at very often, but we have two starting pitchers with suspect stat lines in Cade Povich and Lucas Giolito. There is also the very attractive +180 number attached to it. I was already looking at the OVER in the F5 innings anyways, which is 4.5 +100, so why not just roll the dice a little here and grab the plus-money?

MLB Best Bets: Orioles/Red Sox Both Teams to Score 2+ Runs F5 (DraftKings +180)

MLB Picks Today Recap

  • Phillies -1.5 runs F5 for 1 unit (DraftKings -125)
  • Phillies OVER 3.5 runs for 1 unit (DraftKings -130)
  • Orioles/Red Sox Both Teams to Score 2+ Runs F5 (DraftKings +180)

ABOUT THE AUTHOR
Known as “Rath” in the Daily Fantasy Sports (DFS) community, he has helped run operations for two prominent daily fantasy sports startups. Michael has taken his insider knowledge and expertise in daily fantasy sports to the content side. Rath won the 2016 FSWA "Baseball Article of the Year, Online" award and was a finalist for the FSWA Best Baseball Series in 2011.
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