A few teams on Monday's five-game slate have already qualified for the 2018 World Cup, which means we could see some serious squad rotation.
Germany have already booked their ticket to the 2018 World Cup in Russia, which means we could see some significant lineup rotation Sunday against Azerbaijan.
Slovakia are the biggest favorites on Sunday's early six-game slate, but Poland, England and Denmark are also expected to dominate their matches.
The Red Bulls control their postseason destiny, and they'll look for Sacha Kljestan to lead them to victory Saturday against Vancouver.
While Belgium have plenty of players who fantasy managers love to pick, they are far from the biggest favorites on Saturday's early four-game slate.
Netherlands, France and Switzerland are all big favorites on Saturday's late four-game slate, and Antoine Griezmann comes in with the best anytime goal scoring odds.
The United States needs a win at home against Panama on Friday to keep their World Cup hopes alive, and they'll be looking to Christian Pulisic to make an impact.
Andrew Laird, Schuyler Redpath and JD Bazzo preview this weekend's three Major League Soccer matches, which are being played over an international break when many national teams are trying to book their tickets to the 2018 World Cup in Russia.
Spain have a very easy match at home against Albania to solidify their spot in the 2018 World Cup, and bookmakers are expecting plenty of goals.
There are a number of players away on international duty this weekend, but Sacha Kljestan is still around to help the Red Bulls solidify their postseason spot.
Andrew Laird and Jordan Cooper discuss bankroll management strategies, including what questions to consider before entering your first contest and why there is no single answer for
Argentina has had a tough path to World Cup qualification, but there is a chance they could book their ticket to Russia if they beat Peru on Thursday and get help elsewhere.
England are heavy favorites as they host Slovenia on Thursday, and bookmakers are expecting Harry Kane to make an impact.
While two teams will play twice in Round 31, Adam Zdroik makes the case for Atlanta's Hector Villalba to get the captain's armband despite having just one game.
Major League Soccer's 31st round of matches includes only five games, including two teams playing twice, but fantasy managers may still be able to rely on the Red Bulls' Sacha Kljestan.
Andrew Laird and Jordan Cooper review Saturday's daily fantasy Premier League slate, which saw many people turning to Manchester United's Romelu Lukaku in cash games.
Arsenal are heavy favorites at home against Brighton on Sunday, and the bookmakers are expecting a solid performance from Alexandre Lacazette.
David Villa looks set to start for NYC FC on Saturday against the Fire, but RotoWire's JD Bazzo explains why that makes another NYC attacker more attractive than paying up for Villa.