The best weekend of the NFL season is here, as the Divisional Round of the 2025-26 NFL Playoffs kicks off in a few hours. If you're looking to stay up to date on the latest odds and predictions for the Divisional Round, the RotoWire staff has you covered. Below, you'll find a quick-hitting breakdown of the latest odds and our staff's expert prediction for both Saturday games of the Divisional Round.
And make sure you check out the Best Saturday Divisional Round Anytime TD Bets as well.
Latest NFL Odds: Divisional Round (Saturday Games)
All odds listed in the section below are courtesy of bet365. Be sure to use a bet365 bonus code to make the most of your bets. Note that odds may change after this article is published.
📅 Matchup | 📊 Point Spread | 💰 Moneyline | 📈 Over/Under |
| Buffalo Bills vs. Denver Broncos | Broncos -1.5 (-106) | Broncos -122 | 45.5 |
| San Francisco 49ers vs. Seattle Seahawks | Seahawks -7 (-102) | Seahawks -300 | 44.5 |
What Game Has the Biggest Point Spread on Saturday in the Divisional Round?
The biggest point spread on Saturday belongs to the Seahawks, who are seven-point favorites against the 49ers. Seattle beat SF, 13-3, in a pivotal Week 18 game the last time these two met. Notably, that would have covered this spread.
- ⭐️ For prop bettors: Best Divisional Round Player Props
What Game Has the Smallest Point Spread on Saturday in the Divisional Round?
The smallest point spread on Saturday belongs to the Denver Broncos, who are currently 1.5-point favorites over the Buffalo Bills. These odds vary from sportsbook to sportstbook, as Buffalo is still favored at a few notable books.
What Game Has the Highest Over/Under on Saturday in the Divisional Round?
The highest over/under point total belongs to the Bills vs Broncos game, which has been set at 45.5 at most sportsbooks.
What Game Has the Lowest Over/Under on Saturday in the Divisional Round?
The lowest over/under point total is the 49ers vs Seahawks matchup, which comes in at 44.5 at most oddsmakers.
Expert Predictions for NFL Divisional Round (Saturday Games)
We asked four RotoWire Staff members to make a moneyline prediction for both of the games on Saturday in the Divisional Round. Here are the results:
Matchup | Max | Blake | Tyler | Brandon |
| Buffalo Bills vs. Denver Broncos | Bills | Bills | Bills | Bills |
| San Francisco 49ers vs. Seattle Seahawks | Seahawks | Seahawks | 49ers | Seahawks |
Bills vs Broncos Staff Predictions
No disagreement here – all four RotoWire staff members are picking the Bills to beat the Broncos.
- ⭐️ For in-depth analysis: Bills vs Broncos Predictions and Odds
49ers vs Seahawks Staff Predictions
This one is not quite as cut-and-dry, but there's still a clear consensus. Three of the four RotoWire staff members are taking the Seahawks to beat the 49ers.
- ⭐️ For in-depth analysis: 49ers vs Seahawks Predictions and Odds
Where to Bet on NFL Playoffs Odds: Divisional Round
Below, I've listed the top sportsbooks that offer betting markets on these games. I've also included their welcome offers, so you can kickstart your account with some bonus bets.
| 📕 Sportsbook | 💰 Promo Code | 🎁 Welcome Offer |
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| bet365 Sportsbook | ROTOWIRE | Bet $5, Get $150 in Bonus Bets |
| TheScore Bet Sportsbook | ROTO | Bet $10, Get $100 in Bonus Bets If Your Bet Wins |
