Bafetimbi Gomis has the best goal-scoring odds for Friday's three-game interleague slate, which includes matches from La Liga, Ligue 1 and the FA Cup.
Getting a piece of the Manchester United attack will be important when they line up against Stoke City, putting Henrikh Mkhitaryan firmly in play.
Eden Hazard is likely to get plenty of fantasy attention Sunday, as Chelsea will host a Hull side that has been leaking goals all season.
Zlatan Ibrahimovic has 10 goals in his last 10 games, and he'll head into Saturday's match against Stoke City with the best goal-scoring odds on the slate.
You'll never guess, but Cristiano Ronaldo has a great chance for a big fantasy score this weekend as Real Madrid host Malaga on Saturday.
Saturday's six-game slate is highlighted by the big Manchester City v. Tottenham clash, but there are plenty of fantasy points up for grabs from players like Manchester United's Henrikh Mkhitaryan.
Manchester United's Henrikh Mkhitaryan has scored double-digit fantasy points in six of his last seven starts, and the Red Devils will need him to be prolific if they want some points Sunday against Liverpool.
Sunday's two-game slate will make for tricky roster decisions because of no late swap, but Paul Pogba's spot in the starting XI is basically guaranteed.
Olivier Giroud has scored in three straight league games, and a matchup against Swansea City on Saturday should give him a great opportunity to extend his streak.
Mesut Ozil is expected to return from an illness, and he has an excellent matchup against Swansea to produce lots of fantasy points.
Sergio Aguero has the best goal-scoring odds for Sunday's two game slate, though much of the day's talk will be about the huge Manchester United-Liverpool match.
Real Madrid headline Sunday's La Liga slate, though their matchup against Sevilla isn't likely to produce a ton of fantasy points.
Barcelona are heavy favorites Saturday against Las Palmas, and the bookmakers think Lionel Messi's a near sure thing to score at least one goal.
There are five road favorites during Saturday's seven-game slate, with Arsenal as the top one against Swansea at the Liberty Stadium.
With Barcelona on the slate, fantasy owners are presented with the big question of who to choose between Lionel Messi, Neymar and Luis Suarez.
Real Madrid are heavy favorites in their first match after the winter break, which means fantasy players will be looking squarely toward Cristiano Ronaldo.
In his debut column for RotoWire, Jordan Cooper breaks down the key differences between small and large slates for DFS soccer contests and what players should focus on when they prepare their lineups.
Alexis Sanchez hasn't scored in two straight games, but he's taken 17 shots over that span and could certainly break through Tuesday against Bournemouth.