Manchester United are the biggest favorites on the slate as they take on Watford at Old Trafford, which puts Henrikh Mkhitaryan in the fantasy spotlight.
Don't look now, but Bafetimbi Gomis has the best goal-scoring odds among the six teams playing Wednesday; but are they high enough to consider him for cash games?
Edinson Cavani has the best goal-scoring odds on Tuesday's two-game interleague slate, but someone else averages over a shot-per-90 more than the PSG frontman.
Gonzalo Higuain has scored in six consecutive Serie A matches, and Juventus will need him to keep up his excellent play against Inter Milan on Sunday.
No one has better goal-scoring odds than Sergio Aguero on Sunday's two-game slate.
Everton take on a Bournemouth side that has allowed 16 goals in their last seven matches, which puts the fantasy spotlight on Everton striker Romelu Lukaku.
Andrew joins FNTSY Sports Network's Full 90 Fantasy show to discuss the Saturday Matchweek 24 Fanduel slate in the Premier League.
Romelu Lukaku has the second-best goal-scoring odds on the slate, but he may not be the Everton forward worth targeting Saturday against Bournemouth.
Four of the top six teams in the table aren't on Saturday's main slate, but with Spurs taking on Boro at White Hart Lane, Harry Kane figures to draw plenty of attention from fantasy players.
Another Friday match means Marseille is back on the interleague slate, forcing fantasy players to decide whether Bafetimbi Gomis is worth the investment again.
With Manchester United expected to take care of business against Hull City on Wednesday, Henrikh Mkhitaryan could be in for a big game.
With two of the top three most expensive midfielders ineligible, Man City's Kevin De Bruyne is likely to be heavily owned Wednesday.
Manchester United are big favorites facing Hull at home, which means Zlatan Ibrahimovic should get plenty of attention from fantasy players.
Sunderland come into Tuesday's match without three starting defenders, which means Tottenham's Harry Kane could have a field day.
Sunday's three-game interleague slate includes two heavy favorites, including Real Madrid, which means fantasy players will have to decide whether or not to invest heavily into Cristiano Ronaldo.
Dele Alli has scored eight goals in his last six league games, but is he the Spurs attacker that fantasy players should rely on Tuesday?
Arsenal players are likely to get plenty of fantasy attention for Tuesday's slate, as they'll face off against a Watford side that's allowed multiple goals in three of their last four league matches.
Atletico Madrid are the biggest favorites on Saturday's three-game slate, which does not include Real Madrid or Barcelona, putting Antoine Griezmann firmly in consideration for fantasy players.