Arsenal's home match against Burnley pushes a number of Gunners up the rankings, with Alexis Sanchez easily taking the top spot among midfielders.
Saturday's six-game slate is highlighted by the big Manchester City v. Tottenham clash, but there are plenty of fantasy points up for grabs from players like Manchester United's Henrikh Mkhitaryan.
Understanding formations and what certain players are responsible for goes a long way in figuring out where the fantasy points will be on certain slates. Jordan Cooper breaks down the key points to focus on.
Andrew Laird and Mike Gottlieb break down what happened in Gameweek 21 of the Premier League, including big wins from Chelsea and Arsenal, before discussing their new Togga strategy tests about whether scrubs can outperform stars.
Manchester United's Henrikh Mkhitaryan has scored double-digit fantasy points in six of his last seven starts, and the Red Devils will need him to be prolific if they want some points Sunday against Liverpool.
Sunday's two-game slate will make for tricky roster decisions because of no late swap, but Paul Pogba's spot in the starting XI is basically guaranteed.
Olivier Giroud has scored in three straight league games, and a matchup against Swansea City on Saturday should give him a great opportunity to extend his streak.
Andrew Laird and Chris Owen preview the upcoming weekend of Premier League matches, with a number of ugly encounters Saturday before two enticing matchups Sunday.
Mesut Ozil is expected to return from an illness, and he has an excellent matchup against Swansea to produce lots of fantasy points.
Sergio Aguero has the best goal-scoring odds for Sunday's two game slate, though much of the day's talk will be about the huge Manchester United-Liverpool match.
Real Madrid headline Sunday's La Liga slate, though their matchup against Sevilla isn't likely to produce a ton of fantasy points.
Barcelona are heavy favorites Saturday against Las Palmas, and the bookmakers think Lionel Messi's a near sure thing to score at least one goal.
Olivier Giroud has a goal in four straight games in all competitions, and Arsenal's matchup against Swansea City this weekend will likely make him a popular captain option.
There are five road favorites during Saturday's seven-game slate, with Arsenal as the top one against Swansea at the Liberty Stadium.
Coming off their big win against Chelsea, Spurs are solid favorites this weekend against West Brom, putting Danny Rose firmly in the fantasy spotlight.
Jordan Cooper discusses how DFS players can react to a downturn in positive results and then dives into this week's question about contest selection based on entry fee.
With Barcelona on the slate, fantasy owners are presented with the big question of who to choose between Lionel Messi, Neymar and Luis Suarez.
Real Madrid are heavy favorites in their first match after the winter break, which means fantasy players will be looking squarely toward Cristiano Ronaldo.