Barcelona have to make up a big 3-0 deficit to Juventus, and if they are to do it, it'll take big performances from Lionel Messi and Neymar.
Borussia Dortmund need to make up a big deficit to overcome Monaco, and if they are to do it, Pierre-Emerick Aubameyang is likely to play a part.
Despite struggling lately and being away from home, Arsenal are the biggest favorites on Monday's two-game slate, with Alexis Sanchez expected to carry the load once again.
Sunday's Manchester United v. Chelsea match is expected to be much closer than their initial encounter this season, with United likely to rely heavily on Zlatan Ibrahimovic.
Sacha Kljestan has started off slowly this season, but JD Bazzo is expecting a breakout performance Saturday against D.C. United.
Sergio Aguero has the second-best anytime goal-scoring odds on the slate, but Kevin Swanson explains why he may be a key differential on Saturday.
Romelu Lukaku leads the Premier League in goals scored this season, and he has an excellent opportunity to add to his total Saturday against Burnley.
Andrew Laird and Mike Gottlieb preview Gameweek 33 of the Premier League, including whether Dele Alli's incredible run of form will continue and whether Chelsea will get a solid result against Manchester United at Old Trafford.
Sebastian Giovinco finally grabbed his first goal of the season last week, and he grabs two first-place votes in this week's rankings.
David Villa has three goals and two assists in his last four games, and he'll look to add to his totals against the struggling Union on Friday.
A number of Spurs players could get attention from fantasy managers this weekend, and Adam Zdroik makes the case for Dele Alli to grab the captain's armband.
After coming off the bench in his return from injury last week, Harry Kane moves up this week's rankings thanks to Tottenham's home match against Bournemouth.
Romelu Lukaku has a league-high 23 goals this season, and he is expected to add to his total this weekend against Burnley at Goodison Park.
Atletico Madrid are the biggest favorites on this week's slate, but is Antoine Griezmann the best place to go for fantasy points?
Everton have a number of solid fixtures as the Premier League season winds down, and while Romelu Lukaku will get plenty of fantasy attention, RotoWire's Nick Pitner says don't forget about Tom Davies.
The Borussia Dortmund-Monaco matchup is expected to be high scoring, with Pierre-Emerick Aubameyang likely to contribute.
The Champions League quarterfinal matchups are stacked with high-end fantasy options, with Cristiano Ronaldo looking to make an impact against Bayern Munich in Germany.
Manchester United are heavy favorites over Sunderland on Sunday, even at the Stadium of Light, which means many fantasy managers will be looking toward Zlatan Ibrahimovic.