Four teams play twice in Round 10, and with Toronto FC among them, Sebastian Giovinco easily takes a top spot in this week's positional rankings.
With not many goals expected to be scored during this week's matches, solid peripheral players like Casemiro could be very helpful to fantasy managers.
While the matchup against Atletico Madrid is far from easy, fading Cristiano Ronaldo could be detrimental during this week's two-game Champions League slate.
Kylian Mbappe has been almost unstoppable of late, but he'll now have to face off against arguably the best defensive team in the world.
Nicolas Lodeiro is one of the most expensive players on Saturday's slate, but JD Bazzo explains why the Sounders midfielder is worth the investment.
Manchester City are the biggest favorites on Sunday's three-game slate, which means plenty of fantasy managers are likely to turn to Kevin De Bruyne.
Manuel Lanzini has created a bunch of chances recently, and he'll look to continue doing so against Stoke City at the bet365 Stadium.
With most upper-tier fantasy options missing from Saturday's five-game slate, is it worth paying up for Leicester City's Riyad Mahrez?
Andrew Laird and Mike Gottlieb preview Gameweek 35 of the Premier League, including a Saturday slate that is highlighted by Christian Benteke, Jermain Defoe and Manolo Gabbiadini. Can you feel the excitement??
Saturday's five-game slate doesn't include many of the Premier League's stars, which means fantasy managers could be drawn to players like Leicester City's Jamie Vardy.
Andrew Laird, Schuyler Redpath and JD Bazzo break down the upcoming weekend of MLS matches, including what the ideal formations may be in MLS Fantasy Manager and how to fit in Romain Alessandrini and Nicolas Lodeiro on DraftKings' late Saturday slate.
Gonzalo Higuain could be a popular pick on Friday's three-game slate, but he doesn't have the best anytime goal-scoring odds.
Manchester City appear to have the easiest matchup of the weekend fixtures, which means plenty of fantasy managers will consider Sergio Aguero for the captain's armband.
While the Dynamo have been better than expected this season, that's not stopping Adam Zdroik from making Sebastian Giovinco his top captain option this weekend.
Manchester City face off against lowly Middlesbrough this weekend, which pushes Kevin De Bruyne up the positional rankings.
Sporting KC have a solid matchup at home against Real Salt Lake this weekend, and our MLS fantasy experts are high on Jimmy Medranda.
The Manchester derby will get plenty of attention, but it may not be the best place for fantasy points on Thursday's three-game slate.
With a number of upper-tier options to choose from on Wednesday's three-game slate, Middlesbrough's Adama Traore could be a key salary-saving option.