With the top five teams in the table playing Sunday, fantasy players could be looking to stack Liverpool as they face off against West Ham at London Stadium.
With Arsenal away to Manchester City and Chelsea hosting Manchester United, many fantasy managers could turn toward Christian Eriksen, who will get to face Crystal Palace at Wembley Stadium.
After a disappointing 1-1 draw in Cyprus two weeks ago, Borussia Dortmund are expected to come out swinging at home against Apoel Nicosia on Wednesday.
Andrew Laird and Tom Devine preview Wednesday's seven-game fantasy Champions League slate, including which Liverpool players should be targeted (hint: all of them) and how to navigate the Spurs-Real Madrid and Napoli-Man City clashes.
Liverpool are big favorites at home against Maribor on Wednesday, and their attacking group is likely to get plenty of attention from fantasy players.
Atletico Madrid need a big performance out of Antoine Griezmann against Qarabag on Tuesday if they want to have a realistic shot at advancing to the group stage.
Despite possibly being without Philippe Coutinho, Liverpool are the biggest favorites on Wednesday's Champions League slate, and Mohamed Salah could have a major impact.
Paris Saint-Germain's home match against Anderlecht will have plenty of fantasy players targeting Neymar, who returns after serving a one-match domestic ban.
Andrew Laird and Jordan Cooper review this past weekend's daily fantasy Premier League slate, including how much Manchester City exposure they had, and then preview Tuesday's eight-game Champions League slate.
Fantasy players are likely to flock to Neymar for Tuesday's eight-game Champions League slate, with PSG heavily favored against Anderlecht.
Inter Milan are the biggest favorites on Monday's four-game slate, and the bookmakers are expecting fireworks from Mauro Icardi.
Florian Thauvin is on a roll for Marseille, and he'll look to keep it going Sunday against Lille.
Riyad Mahrez has been a disappointing fantasy option for much of this season. Could his breakout game come Sunday at home against Everton?
Liverpool, Arsenal and Manchester City are the three biggest favorites on Saturday's six-game slate, but getting a piece from each might be too tough without punting at least one spot.
Andrew Laird and Mike Gottlieb preview the upcoming weekend of Premier League matches, including whether Swansea or Huddersfield put up a bigger fight against Arsenal and Liverpool, respectively.
Liverpool will look to bounce back after getting thrashed by Tottenham last weekend, which means fantasy owners will have to decide which attackers to prioritize.
Andrew Laird and Luis Pacheco preview this Saturday's daily fantasy Premier League slate, which will have Arsenal, Liverpool, Manchester City and Chelsea all playing as heavy favorites.
Man City are likely to dominate possession during Saturday's match at West Brom, which will make plenty of their players popular fantasy options on The Six.