Bayern Munich are expected to score plenty of goals at home against Celtic on Wednesday, and Arjen Robben is likely to have a hand in at least one.
Paris Saint-Germain are big favorites playing at Anderlecht on Wednesday, which means plenty of fantasy managers will try to build around Neymar.
The heavy hitters are out for Wednesday's seven-game Champions League slate, with Paulo Dybala looking to break a three-match goalless drought.
Some fantasy managers may stay away from Real Madrid because they're up against Tottenham, but RotoWire's Schuyler Redpath says not to shy away from Marcelo.
Monaco aren't the biggest favorites on Tuesday's eight-game Champions League slate, but bookmakers are still expecting Radamel Falcao to have a big impact.
Monday's three-game interleague slate isn't expected to have many goals, so fantasy managers may need to give Leicester City's Jamie Vardy a longer look than usual.
The Sounders continue to battle for playoff positioning, and RotoWire's Schuyler Redpath is expecting another big performance from the Sounders' Nicolas Lodeiro.
Nemanja Nikolic faces off against a weak Union defense as he tries to get closer to winning the Golden Boot. However, there are two other players close on his heels who also have solid matchups Sunday.
Edin Dzeko has scored seven goals in his last five starts for Roma, but he may find it tough to extend his scoring streak to six games Saturday against Napoli.
Diego Valeri has 10 goals in his last 10 games, and he'll look to get closer to locking up the golden boot at home against D.C. United on Sunday.
Sunday's two-game slate features only one team in the top half of the table.
NYC FC will continue their quest for a top-two spot in the Eastern Conference on Saturday against the Revs, and they'll need David Villa to make a big impact.
Manchester City and Tottenham are likely to get plenty of attention from fantasy players Saturday, but Kevin Swanson reminds us not to forget about Chelsea.
Fantasy players are likely to want lots of exposure to Tottenham and Manchester City on Saturday, which means they'll need plenty of value plays to pair with the high-priced attackers.
Tottenham are heavily favored at home against Bournemouth on Saturday, and midfielder Christian Eriksen is likely to have a big impact.
Tottenham aren't the biggest favorites on Saturday's six-game slate, but striker Harry Kane has the highest anytime goal-scoring odds.
The United States can book their ticket to Russia with a result at Trinidad & Tobago on Tuesday, and they come into the three-game slate as the heaviest favorites.
Argentina need a result in Ecuador to book their ticket to the World Cup, and they'll be relying heavily on Lionel Messi to get them there.