Thursday's two-game interleague slate includes four teams from La Liga, and with no Barcelona, Real Madrid, Atletico Madrid or Sevilla available, fantasy players will really have to do their homework.
Manchester City are the biggest favorites on Saturday's seven-game slate, but stacking them might be tough on most sites because of their high salaries.
Paris Saint-Germain are huge favorites over Caen, which means plenty of fantasy players are likely to build their teams around Neymar.
Lorenzo Insigne could be a popular option on Tuesday's two-game slate, but he may not even start if Napoli rotate for their opening Coppa Italia match.
Swansea City haven't won away from home since August, but they'll look for Jordan Ayew to help break the streak Monday at Everton.
Liverpool and Manchester United are both big favorites on Sunday's two-game slate, but fitting in all the high-powered stars will be tough to do in a single fantasy lineup.
Arsenal are big favorites at home against Newcastle on Saturday, which means fantasy players will be expecting a solid performance out of Alexis Sanchez.
Leroy Sane hasn't found the back of the net in quite a while, and while the matchup Saturday against Spurs isn't the easiest, City are still expected to be comfortably in control.
Xherdan Shaqiri is one of the most expensive midfielders on Saturday's six-game slate, but could fading him be too detrimental?
Chelsea are heavy favorites at home against Southampton on Saturday, and fantasy owners should turn their attention to defender Cesar Azpilicueta.
Manchester City have a tough matchup at home against Tottenham on Saturday, but the oddsmakers still think Sergio Aguero has a good chance to find the back of the net.
Mohamed Salah and Philippe Coutinho get all the attention for those looking at Liverpool, but Roberto Firmino is in great form as well.
Sergio Aguero's price has dropped after two straight matches without a start, but he could be the best value on the board if he makes his way back in Wednesday.
Harry Kane was the chalk forward this past Saturday, and given his matchup at home against Brighton on Wednesday, we could be looking at more of the same.
Tottenham are big favorites at home against Brighton on Wednesday, and while Harry Kane is always a hat trick candidate, don't forget about Son Heung-Min.
Andrew Laird and Jordan Cooper preview Wednesday's seven-game daily fantasy Premier League slate, which could be greatly affected if Philippe Coutinho doesn't start for Liverpool.
Wednesday's seven-game slate has some big favorites, including Liverpool, Man City, Man United and Tottenham, which means fantasy players will have to make some tough decisions on who to fade.
Andrew Laird and Jordan Cooper review this past Saturday's daily Fantasy Premier League action and then preview Tuesday's three-game slate, which will be heavily dependent on what Chelsea do with their lineup.