Luka Mitrovic and Red Star host Valencia and help tip off both a five-game Tuesday and the latest double-game week.
Five games will go off Thursday, and the action concludes with another rematch of last year's Final between Olympiacos and Sergio Rodriguez's Real Madrid club.
The first day of action in Round 22 features five games, and one of them will be an all-German matchup between Sylvain Francisco's Bayern club and ALBA.
Edmond Sumner and Zalgiris take on Barcelona and help bring an end to the busiest stretch of the season.
Another Round tips off Thursday, and the action will begin with a matchup between Bayern and a Fenerbahce club featuring Tarik Biberovic.
It will be a light Wednesday amid the latest double-game week, and the first of two games will involve Isaiah Canaan's Olympiacos club and Barcelona.
A second straight double-game week begins in a busy way, as Juancho Hernangomez and Panathinaikos host Efes in one of the seven games on Tuesday's schedule.
The Eternal Derby will go down again Thursday as Rokas Giedraitis and Red Star square off against Partizan in Stark Arena.
The latest edition of El Clasico will take place Wednesday, and a Barcelona club led by Nicolas Laprovittola will be looking for a much-needed win against rival Real Madrid.
A new year of EuroLeague play gets underway Tuesday, and a new era begins for Zalgiris, as Austin Hollins and co. move forward with a new coach.
The first half of the regular season comes to a close Friday, and the final game on the docket will be a big-time matchup between Kemba Walker's Monaco club and Barcelona.
A whopping seven games will be played Thursday, but there will be no shortage of eyeballs on Istanbul, where Shane Larkin and Efes are set to host Fenerbahce.
It will be a busy Friday in the EuroLeague, and in the fourth of the six scheduled contests Malte Delow and ALBA will face off against Fenerbahce.
Things may look a bit different than they did back in May, but for the first time since last season's fierce playoff matchup, Kevin Punter and Partizan will square off against Real Madrid.