Enner Valencia had a brace in Tuesday's win over Bournemouth, and with Diafra Sakho and Andy Carroll sidelined by injuries, he is slated for significant playing time leading the Hammers' attack.
Gylfi Sigurdsson appears to be turning it around after struggling to start the season, and a home match against Sunderland could allow for a breakout performance.
Hesh Hambazaza breaks down the key stat to focus on when looking for players with the highest fantasy floors on DraftKings.
After scoring in Arsenal's FA Cup win over Sunderland this past weekend, Olivier Giroud now sports 16 goals in 21 starts this season, and he takes the Best XI captain's armband for Week 21.
Bakary Sako is back from his hamstring injury and could be a difference-maker in Crystal Palace's match against last-place Aston Villa on Tuesday.
Diego Costa looks renewed under interim manager Guus Hiddink, and he could continue his fine play Wednesday against West Brom.
Playing against an Everton defense that has struggled this season and will be without Seamus Coleman, Sergio Aguero takes the top spot in one of the positional rankings this week.
Andrew Laird and Mike Gottlieb preview Gameweek 21 of the Premier League, a set of midweek matches that could force managers into some squad rotation with the next set of fixtures in as little as three days.
Andrew Laird and Mike Gottlieb reveal the teams they made for Segment 2 of ESPN's Premier Fantasy game and discuss how they possibly became finalists for the 2015 FSWA Best Podcast Award.
Andrew Laird introduces his Goal Differential Form Table and explains why Gameweek 21 may finally be the time Swansea break out.
Mesut Ozil is one of the most expensive options on the board for Saturday's slate, but RotoWire's Alex Spalding has a number of value plays to fit the Arsenal midfielder into fantasy lineups.
Andrew Laird and Mike Gottlieb preview Gameweek 20 of the Premier League, including what of squad rotation there might be and whether Stoke can keep their high-flying ways going.
Despite failing to score in three consecutive Premier League games, a home match against Bournemouth moves Jamie Vardy to the top of the forwards rankings.
Jamie Vardy's electric season has slowed down a bit recently, but the Premier League co-leader in goals could get back on track soon, according to Hesh Hambazaza.
While Romelu Lukaku and Ross Barkley often get the attention as Everton's best attackers, RotoWire's Tate McIntyre reminds fantasy owners that they shouldn't ignore another piece of the Toffees' attack.
Romelu Lukaku has scored 10 goals in his last nine league games, and he's got a great opportunity this weekend to extend his streak.
Arsenal are trying to bounce back from a surprising 4-0 loss to Southampton on Boxing Day, and they'll look to Olivier Giroud, who has six goals in his last five games in all competitions.
Looking to bounce back from a surprising 4-0 loss to Southampton on Boxing Day, Arsenal's Petr Cech will try again for the Premier League clean sheet record Monday against Bournemouth.