Romelu Lukaku has the second-best goal-scoring odds on the slate, but he may not be the Everton forward worth targeting Saturday against Bournemouth.
Andrew Laird and Mike Gottlieb break down the upcoming weekend fixtures in the Premier League, which starts off with the big RotoClasico of Chelsea v. Arsenal.
No team has allowed more forwards to make the weekly Perfect XI lineup than Swansea, putting Sergio Aguero firmly in play this weekend.
With Tottenham expected to take care of business at home against Middlesbrough this weekend, fantasy managers should look to Dele Alli as a potential captain.
Four of the top six teams in the table aren't on Saturday's main slate, but with Spurs taking on Boro at White Hart Lane, Harry Kane figures to draw plenty of attention from fantasy players.
There are plenty of disagreements among the midfielder group for this weekend, but Kevin De Bruyne comfortably sits at the top.
Another Friday match means Marseille is back on the interleague slate, forcing fantasy players to decide whether Bafetimbi Gomis is worth the investment again.
With Manchester United expected to take care of business against Hull City on Wednesday, Henrikh Mkhitaryan could be in for a big game.
With two of the top three most expensive midfielders ineligible, Man City's Kevin De Bruyne is likely to be heavily owned Wednesday.
Manchester United are big favorites facing Hull at home, which means Zlatan Ibrahimovic should get plenty of attention from fantasy players.
Sunderland come into Tuesday's match without three starting defenders, which means Tottenham's Harry Kane could have a field day.
Andrew Laird and Mike Gottlieb preview the upcoming midweek Premier League fixtures, which include a number of road favorites Tuesday and some big mismatches Wednesday.
Sunday's three-game interleague slate includes two heavy favorites, including Real Madrid, which means fantasy players will have to decide whether or not to invest heavily into Cristiano Ronaldo.
Arsenal are big favorites against Watford on Tuesday, which means Togga Perfect XI players could be drawn to Theo Walcott, who bagged a hat trick in FA Cup action this weekend.
Dele Alli has scored eight goals in his last six league games, but is he the Spurs attacker that fantasy players should rely on Tuesday?
Arsenal players are likely to get plenty of fantasy attention for Tuesday's slate, as they'll face off against a Watford side that's allowed multiple goals in three of their last four league matches.
Arsenal host Watford on Tuesday, which means plenty of fantasy managers will be focusing on Alexis Sanchez.
Atletico Madrid are the biggest favorites on Saturday's three-game slate, which does not include Real Madrid or Barcelona, putting Antoine Griezmann firmly in consideration for fantasy players.