Wednesday's Liverpool-Man City match will get plenty of attention, but the big decision for the two-game slate will be whether or not to roster Lionel Messi.
The favorites on Tuesday's two-game slate are playing away, and fantasy players will likely have to make the tough decision of choosing between Cristiano Ronaldo and Robert Lewandowski.
Atletico Madrid are without Antoine Griezmann on Sunday, but they are still heavily favored at home to Deportivo.
Arsenal face a struggling Stoke City side at the Emirates on Saturday, which means Pierre-Emerick Aubameyang is likely to be a popular fantasy selection.
Fantasy players are likely to focus on Tigres at home against Leon for Saturday's three-game slate, though there should be fantasy points to be had from all six teams.
Josef Martinez is fresh off a hat trick and is looking for more Saturday at Minnesota, the site of his first MLS hat trick last season.
Lionel Messi headlines Saturday's four-game interleague slate, but a tough matchup at Sevilla doesn't make him as easy to play as usual.
Zlatan Ibrahimovic's arrival in MLS will dominate the attention Saturday, but Nemanja Nikolic has a great opportunity for a breakout game at home against Portland.
Toronto FC are still looking for their first goal of the 2018 MLS season, and they'll look toward Sebastian Giovinco to break through Friday against Real Salt Lake.
With Sergio Aguero potentially sidelined with injury, a few other Man City attackers will have to step up Saturday at Everton.
Alexis Sanchez and Romelu Lukaku will get most of the attention for fantasy players looking for exposure to Manchester United, but don't forget about Marcus Rashford if he starts.
With Sergio Aguero unlikely to start Saturday at Everton, more of the scoring load for Manchester City could fall to Raheem Sterling.
Andrew Laird and Mike Gottlieb preview Gameweek 32 of the Premier League, including whether Liverpool will score more goals at Crystal Palace than Manchester City at Everton.
Manchester United's expected dominance of Swansea City on Saturday is likely to cause plenty of fantasy players to focus on attackers like Romelu Lukaku, Alexis Sanchez and Paul Pogba.
Fantasy players are likely to to give long looks at Romelu Lukaku as Manchester United host Swansea City on Saturday, but he may not be the best option for cash games.
Cardiff are big favorites and have the highest implied goal total as they host Burton Albion as part of Friday's six-match slate.
Manchester United will host Swansea City at Old Trafford on Saturday, which means plenty of fantasy players could be stacking the Red Devils.
Andrew Laird and Jordan Cooper preview Saturday's daily fantasy Premier League slate, which includes both Manchester clubs as decent favorites even though one is playing away.