Sunday's marquee matchup of the Red Bulls at Atlanta United figures to have plenty of fireworks, pushing fantasy players toward Miguel Almiron.
NYC FC is expected to handle the Rapids at Yankee Stadium on Saturday, which means Maxi Moralez could be a popular fantasy option.
Chelsea missed out on qualifying for next season's Champions League, but they still have an opportunity to win a trophy Saturday against Manchester United.
Toronto will be without Sebastian Giovinco and Jozy Altidore on Friday, but they are still strong favorites to beat Orlando City.
Thursday's opening leg of the 2018 Clausura final is expected to be a tightly contested affair, with Santos favored as the home team.
The Whitecaps are heavily favored at home against the Earthquakes on Wednesday, but will fantasy players trust Kei Kamara to find the back of the net?
Atletico Madrid are strong favorites to beat Marseille in the Europa League final on Wednesday, with Antoine Griezmann coming in with the best anytime goal scorer odds.
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Ignacio Piatti disappointed during the Week 11 double gameweek, but he has a great opportunity to bounce back against the Galaxy, making him a solid captain differential.
Two teams will play twice in Week 12, but that's not enough to push Josef Martinez out of JD Bazzo's top three forwards in his weekly positional rankings.
Andrew Laird and JD Bazzo preview Week 12 of the MLS Fantasy season, one that includes a double gameweek for the Whitecaps and Earthquakes.
Andrew Laird and Jordan Cooper review their daily fantasy Premier League lineups from the last gameweek of the 2017/18 season and then discuss how legalized sports betting will affect daily fantasy sports in the U.S.
Marcus Rashford is likely to have plenty of opportunities Sunday at Watford, and his price makes him well worth consideration.
Harry Kane's quest for his third consecutive Golden Boot will likely have him firing plenty of shots Sunday at home against Leicester City.
Liverpool at home against Brighton sure makes for a great matchup for Mohamed Salah, who is looking to clinch the Premier League single-season scoring record Sunday.
Diego Valeri has four goals in his last five games, and he'll look to stay hot Sunday at home against the Sounders.
Paris Saint-Germain continue to be without Neymar and will miss Edinson Cavani on Saturday, which means Kylian Mbappe will need to step up against Rennes.
Ignacio Piatti failed to do much during the Impact's midweek match at Chicago, but he has a great opportunity to bounce back Saturday at home against the Union.