Friday's three-game slate is highlighted by Spain v. Portugal, though fantasy players may want to focus on the two earlier games for their points.
The World Cup kicks off Thursday when Russia face off against Saudi Arabia, a match the host nation is expected to dominate, which could have plenty of fantasy players stacking Russians.
Russia and Saudi Arabia will open the World Cup on Thursday, with the host nation being gifted one of the easiest matchups of the tournament.
Toronto FC are big favorites at home against D.C. United on Wednesday, which means fantasy players will have to decide if they want to pay up for Sebastian Giovinco.
Saturday boasts a massive 20-team slate, with Zlatan Ibrahimovic coming in with the best anytime goal scorer odds as the Galaxy host Real Salt Lake.
Sebastian Giovinco is averaging over seven shots per 90 minutes this season, and fantasy players will have to decide if he's worth paying up for Friday at Philadelphia.
Andrew Laird and Jordan Cooper discuss a few key strategies for daily fantasy sports players looking to jump into the soccer action during the World Cup.
With Felipe Gutierrez and Johnny Russell out, Sporting KC will need even more out of Graham Zusi at home against Minnesota United on Sunday.
The Timbers have a tough matchup against LA FC on Saturday, but the odds makers are still expecting Diego Valeri to have a big impact in Portland.
Kei Kamara has just one goal in his last six matches, but he'll look to break through against the Rapids on Friday night.
Romain Alessandrini has been the Galaxy's most consistent fantasy producer of late, and he'll look to keep it going at home Wednesday against FC Dallas.
Atlanta United travel to face the Revolution in Foxboro on Wednesday, but that isn't likely to keep fantasy players from rostering Miguel Almiron.
Andrew Laird and Jordan Cooper review their DraftKings showdown lineups from Saturday's Champions League final, and then they discuss ways to build a DFS bankroll based on different investment levels.
Johnny Russell has been one of the more dynamic fantasy producers this season, but he could have a tough time being as active Sunday against the Crew.
With the Red Bulls heavily favored at home against the Union on Saturday, Bradley Wright-Phillips could be a very popular fantasy pick.
Sebastian Giovinco returns from his one-match ban, and he comes back with the best anytime goal scorer odds on Friday's three-game slate.
Cristiano Ronaldo has been absolutely dominant during Champions League play this season, and he'll look to win his third consecutive European trophy Saturday against Liverpool.
Mohamed Salah dominated the Premier League this season, and he'll look to cap off his huge year against Real Madrid in the Champions League final Saturday.