All three away teams are favored Sunday, with fantasy players having to decide how much exposure they need from Arsenal, Manchester United and Tottenham.
Chelsea are expected to have plenty of possession as they host Bournemouth at Stamford Bridge, which means Jorginho could have a very strong fantasy day.
Monterrey are solid favorites away to Puebla on Friday, but Tijuana and Morelia offer plenty as home favorites.
With Richarlison suspended due to a red card last week, RotoWire's Schuyler Redpath is expecting Cenk Tosun and Theo Walcott to step up at home against Huddersfield.
Bertrand Traore has two goals on 14 shots in his first three games, and he'll look to keep his active play going Friday at home to Nice.
Many fantasy players could focus on Manchester City as they host Newcastle at the Etihad Stadium, which means those who target Chelsea at home against Bournemouth could reap the benefits of their lower-owned attackers.
Andrew Laird and Jordan Cooper preview Saturday's six-game daily fantasy Premier League slate, including how much Man City exposure is necessary in cash games and how players can take advantage of that in GPPs.
Despite his high price, Sergio Aguero figures to be a very popular fantasy option as Manchester City host Newcastle on Saturday.
Manchester City are huge favorites at home to Newcastle on Saturday, with fantasy players stuck having to decide how much they want to stack the Citizens.
Portland are favored at home against Toronto on Wednesday, which could push fantasy players to rostering Diego Valeri.
PSV Eindhoven are the biggest favorites on Wednesday's three-game slate, but fantasy players will have to decide how much they want to pay up for their stars.
Ajax have a commanding 3-1 aggregate lead over Dynamo Kyiv after the first leg in the Netherlands, and they are favored to win in Ukraine on Tuesday.
Paul Pogba has scored from the penalty spot in each of the first two matches this season, and he could be a popular GPP option Monday against Spurs.
The Red Bulls will take on a resurgent D.C. United on Sunday, and they'll likely rely on Bradley Wright-Phillips to lead the charge.
First-place Cruz Azul visits third-place Santos Laguna on Sunday, but fantasy players may be better off focusing on Toluca at home against Leon.
Toronto is the second-biggest favorite on Saturday's five-game MLS slate, which means fantasy players will surely be targeting Sebastian Giovinco.
Eden Hazard is apparently not ready to play a full 90 minutes yet, but fantasy players could be tempted to roster him anyway if he starts Sunday at Newcastle.
Josef Martinez has already tied the MLS single-season goal-scoring record, and he'll look to take control of it in Orlando on Friday.